![]() This stimulation phase was preceded by a basal exploration (PRE) and followed by a probe exploration (POST) as described in panel a. Rewarding stimulations were then delivered when mice reached a pre-established area, covering around 5% of the total surface of exploration. Mouse position was tracked in real time with a video camera during a session lasting 15 minutes. This protocol was always followed by free exploration to erase the learning (extinction exploration) and a control wake pairing. As in panel a, the sleep protocol is composed of the same four sessions except that spike-stimulation pairing is performed during 1h of sleep. Analyses were carried on the first 4 trials where animal was actively exploring. In PRE and POST session a minimum of eight 60s-trials with changing starting point (gray circles) is performed. The paradigm consisted in four sessions: 1) free exploration and place field identification, 2) basal exploration (PRE), 3) 15 minutes exploration with pairing where online detected spikes of a given place cell triggered MFB stimulation, and 4) test exploration (POST). Maei, H.R., Zaslavsky, K., Teixeira, C.M. Harris, K.D., Hirase, H., Leinekugel, X., Henze, D.A. Schmitzer-Torbert, N., Jackson, J., Henze, D., Harris, K. Harris, K.D., Henze, D.A., Csicsvari, J., Hirase, H. ![]() Kobayashi, T., Nishijo, H., Fukuda, M., Bures, J. ![]() Lenck-Santini, P.-P., Muller, R.U., Save, E. Girardeau, G., Benchenane, K., Wiener, S.I., Buzsáki, G. The Hippocampus as a Cognitive Map 1–570 (Oxford University Press, 1978). ![]()
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